Multivariable Mendelian Randomization and Mediation
نویسندگان
چکیده
منابع مشابه
5. Mendelian randomization
Associations between modifiable exposures and disease seen in observational epidemiology are sometimes confounded and thus misleading, despite our best efforts to improve the design and analysis of studies. Mendelian randomization, the random assortment of genes from parents to offspring that occurs during gamete formation and conception provides one method for assessing the causal nature of so...
متن کاملPleiotropy-robust Mendelian randomization.
Background The potential of Mendelian randomization studies is rapidly expanding due to: (i) the growing power of genome-wide association study (GWAS) meta-analyses to detect genetic variants associated with several exposures; and (ii) the increasing availability of these genetic variants in large-scale surveys. However, without a proper biological understanding of the pleiotropic working of ge...
متن کاملBilirubin, gallstones, and mendelian randomization.
Gallstonedisease causes a substantialhealthandeconomicburden in theUnited States andother developed countries.More than 6millionmen and 14millionwomen aged 20 to 74 years in the United States have gallbladder disease.1 Approximately 650 000 to 700 000 cholecystectomies are performed annually in the United States, and the costs associated with the symptoms and complications of gallstones are est...
متن کاملMultivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects
A conventional Mendelian randomization analysis assesses the causal effect of a risk factor on an outcome by using genetic variants that are solely associated with the risk factor of interest as instrumental variables. However, in some cases, such as the case of triglyceride level as a risk factor for cardiovascular disease, it may be difficult to find a relevant genetic variant that is not als...
متن کاملUsing Multivariable Mendelian Randomization to Disentangle the Causal Effects of Lipid Fractions
BACKGROUND Previous Mendelian randomization studies have suggested that, while low-density lipoprotein cholesterol (LDL-c) and triglycerides are causally implicated in coronary artery disease (CAD) risk, high-density lipoprotein cholesterol (HDL-c) may not be, with causal effect estimates compatible with the null. PRINCIPAL FINDINGS The causal effects of these three lipid fractions can be bet...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Medicine
سال: 2020
ISSN: 2157-1422
DOI: 10.1101/cshperspect.a038984